Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues
J. Clin. Invest. Thierry Huby, et al. 116:2767 doi:10.1172/JCI26893 [
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Figure 3Impact of changes in SR-BI expression on plasma lipoprotein cholesterol profiles. (
A) Fasting plasma samples (pooled plasma from 6–10 mice) from 2-month-old female mice fed a chow diet were fractionated by size-exclusion chromatography. TC was measured in each fraction to determine lipoprotein cholesterol profiles. Approximate elution volumes for particles in the size ranges of VLDL, LDL, and HDL are indicated. (
B) Electrophoretic mobilities of plasma lipoproteins. Plasma samples (10 μl) were subjected to agarose gel electrophoresis and lipoproteins revealed by Sudan black staining. α, pre-β, and β positions corresponding to migrations of HDL, VLDL, and LDL particles, respectively, are indicated.
