Modulation of atherosclerosis in mice
by Toll-like receptor 2
J. Clin. Invest. Adam E. Mullick, et al. 115:3149 doi:10.1172/JCI25482 [
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Figure 6Measurement of aortic atherosclerosis in Pam3-exposed TLR2 chimeric mice. (
A) Aortic atherosclerosis expressed as a percentage of total area after 12 weeks of an HFD and weekly i.p. injections of Pam3 in female
Ldlr–/– mice that underwent BM reconstitution from
Tlr+/+ or
Tlr2–/– donor mice. (
B–
E) Representative aortae from
Ldlr–/– recipient mice of the following groups:
Tlr2+/+ BM donor, vehicle injection (
B);
Tlr2+/+ BM donor, 50 μg Pam3 per week (
C);
Tlr2–/– BM donor, vehicle injection (
D); and
Tlr2–/– BM donor, 50 μg Pam3 per week (
E). Pam3 administration increased lesion severity in animals expressing TLR2 in their BM-derived cells resulting in profuse abdominal aortic atherosclerosis. Slight increases in lesion severity were observed in
Tlr2–/– recipient animals receiving Pam3. Scale bar: 0.5 cm.
