Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction
J. Clin. Invest. Cinzia Perrino, et al. 116:1547 doi:10.1172/JCI25397 [Go to this article.]

Figure 2
Chronic pathological stress is required to induce the fetal gene expression reprogramming. (A) Gene expression analysis of renal renin in kidneys of swimming, running, iTAC, and cTAC mice by RT-PCR. Data are shown as fold change over control ± SEM. Differences were not significant. (B and C) Gene expression analysis of α and β isoforms of MHC, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), angiotensin II type 1a receptor (ATR), adrenomedullin (AM) and natriuretic peptide receptor A (NPRA) in hearts of swimming, iTAC, and cTAC mice by real-time RT-PCR of LV mRNA. Sedentary animals were used as controls for swimming mice; sham-operated animals were used for iTAC or iTAC. Data are shown as fold change over control ± SEM. ^#P < 0.05 versus swimming; ^‡P < 0.01 versus iTAC; Student’s t test.