Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice
J. Clin. Invest. Xu Peng, et al. 116:217 doi:10.1172/JCI24497 [Go to this article.]

Figure 4
Multifocal interstitial fibrosis of CFKO mice in response to Ang II infusion. (A–D) Cardiac sections from Ang II–infused control (A and C) or CFKO (B and D) mice were stained with H&E (A and B) or Masson trichrome (C and D), as indicated. The interstitial fibrosis in sections from CFKO mice is marked by arrows. Scale bars: 60 μm. (E) Northern blot analysis for collagen I, IV, and VI expression of control or CFKO mice at 14 days after vehicle or Ang II infusion, as indicated. (F) The intensity of the bands was quantified from 3 independent experiments by densitometry. The mean ± SD values of relative intensity (normalized to the control sample treated with vehicle) are shown in arbitrary units. *P < 0.05 compared with values from control mice with Ang II infusion.