Kinetics of protective antibodies are determined by the viral surface antigen
J. Clin. Invest. Daniel D. Pinschewer, et al. 114:988 doi:10.1172/JCI22374 [Go to this article.]

Figure 2
Correlation of nAb induction with the viral surface determinant. C57BL/6 mice were infected i.v. with 2 × 10⁴ PFU rLCMV/INDG (squares), LCMV-ARM (triangles), VSV-IND (inverted triangles), rVSV/LCMV-GP (diamonds), or with 10⁷ PFU rVSV/LCMV-GP (circles). Serum samples collected at the indicated time points were tested in neutralization assays (A_D) or by ELISA (E and F) for total Ig (open symbols) and IgG (filled symbols) with the following specificities: (A) VSV-IND_neutralizing total Ig and _neutralizing IgG; (B) rVSV/LCMV-GP_neutralizing total Ig; (C) rLCMV/INDG_neutralizing total Ig; (D) LCMV-ARM_neutralizing total Ig; (E) VSV-NP_binding IgG; (F) LCMV-NP_binding IgG. Except for ARM-HIS (×) and WEN-3 mAb (+) controls (single samples), symbols generally represent the mean of 3 mice per group ± SD. Due to limitations in the amount of serum collected, for some groups and time points in D_F only 2 out of 3 mice could be tested. One representative of 2 experiments is shown.