Cerebral vessel laminins and IFN-γ define Trypanosoma brucei brucei penetration of the blood-brain barrier
J. Clin. Invest. Willias Masocha, et al. 114:689 doi:10.1172/JCI22104 [Go to this article.]

Figure 2
Immunofluorescent images from the septal nuclei and corpus callosum 20 days p.i. (T. brucei brucei in red and endothelial cells in green). (A) In a WT mouse, numerous parasites were observed in the brain parenchyma of the septum. (B) In an IFN-γ^–/– mouse, parasites were localized in the lumen of blood vessels, here illustrated in the corpus callosum. (C) Also in an IFN-γ^–/– mouse, perivascular aggregates of trypanosomes could be observed in the septal nuclei. (D) In an IFN-γR^–/– mouse, parasites could be found clustered around vessels. Scale bar: 50 μm.