Evidence for a bone-kidney axis regulating phosphate homeostasis
J. Clin. Invest. L. Darryl Quarles, et al. 112:642 doi:10.1172/JCI19687 [Go to this article.]

Figure 1
A bone-kidney axis regulating renal phosphate handling and skeletal mineralization. A phosphaturic hormone, phosphatonin, stimulates renal phosphate excretion. Osteoblasts in bone may be the source of phosphatonin. Increased release of phosphatonin leads to autocrine effects to regulate bone mineralization of ECM and systemic effects to cause phosphaturia.