Stat-3 is required for pulmonary homeostasis during hyperoxia
J. Clin. Invest. Isamu Hokuto, et al. 113:28 doi:10.1172/JCI19491 [
Go to this article.]
Figure 5STAT-3 immunohistochemistry after exposure to 95% oxygen. Lungs from control (
a) and
Stat-3Δ/Δ (
b) mice were stained for
Stat-3 after 72 hours of exposure to 95% O
2. Alveolar type II cells, bronchiolar epithelial cells, and alveolar macrophages were stained in controls.
Stat-3 was detected in inflammatory cells (filled arrows), vascular and stromal cells, but not in epithelial cells (arrowheads), in
Stat-3Δ/Δ mice. Bronchiolar epithelial cell necrosis was prominent (open arrows). Original magnification ×10. Magnification for inserted enlarged photomicrographs ×40.
