Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization
J. Clin. Invest. Keiko Morikawa, et al. 112:1871 doi:10.1172/JCI19351 [Go to this article.]

Figure 5
Inhibitory effect of catalase on EDHF-mediated relaxations and hyperpolarizations of mesenteric arteries. (a) In mesenteric arteries from control mice, catalase (6,250 U/ml) in the presence of indomethacin and L-NNA significantly inhibited EDHF-mediated relaxations (n = 4 each). ***P < 0.0001. (b) In mesenteric arteries from Cu,Zn-SOD^–/– mice, catalase (6,250 U/ml) had no inhibitory effect on the remaining EDHF-mediated relaxations (n = 4 each). (c) Catalase significantly inhibited endothelium-dependent hyperpolarizations in response to ACh (10^–5 M) of mesenteric arteries from control mice (n = 3). *P < 0.05. (d) Catalase had no effect on endothelium-dependent hyperpolarization of mesenteric arteries from Cu,Zn-SOD^–/– mice (n = 3).