Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization
J. Clin. Invest. Keiko Morikawa, et al. 112:1871 doi:10.1172/JCI19351 [
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Figure 1Characterization of
Cu,Zn-SOD–/– mice. (
a) Western blot analysis for SOD isoforms in mesenteric arteries from control (WT) and
Cu,Zn-SOD–/– (KO) mice. Cu,Zn-SOD expression was absent in the
Cu,Zn-SOD–/– mice, whereas the expression of MnSOD and ecSOD was unaltered. (
b) Cu,Zn-SOD activity of mesenteric arteries from the two strains. Cu,Zn-SOD activity was absent in the
Cu,Zn-SOD–/– mice. Comparable activities of glutathione peroxidase (
c) and catalase (
d) of the liver in the two strains (
n = 5 each). (
e) Western blot analysis for eNOS expression in mesenteric arteries (
n = 5 each). eNOS protein expression was comparable between the two strains.
