A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans
J. Clin. Invest. Akihisa Sawada, et al. 112:1707 doi:10.1172/JCI18937 [Go to this article.]

Figure 5
Maturation arrest of B-lineage cells induced by expression of truncated LRRC8 and expression of LRRC8 on normal lymphoid cells. (a) Representative data of B-lineage cell subsets in bone marrow transfected with MIY or MutY. PE, phycoerythrin; APC, allophycocyanin. (b) LRRC8 expression on normal bone marrow and peripheral blood cells. CD19- and CD3-positive cells were gated as human B-lineage and T cells, respectively.