D-β-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
J. Clin. Invest. Kim Tieu, et al. 112:892 doi:10.1172/JCI18797 [Go to this article.]

Figure 3
Protective effect of DβHB against motor deficit in MPTP-treated mice. Animals were infused subcutaneously with either vehicle (saline) or DβHB (1.6 mmol/kg/d) 1 day before receiving intraperitoneal injections of either saline or MPTP (18 mg/kg). Pumps were removed at day 7, and animals were allowed to recover from surgery and dehydration for an additional 7 days before their Rotarod performance was assessed. Motor deficit is observed in the MPTP-treated animals, but DβHB significantly improves this impairment. DβHB does not affect base-line motor function in saline-injected mice. n = 4–13; *P < 0.05 compared with the saline-vehicle group; ^#P < 0.05 compared with the MPTP-vehicle group.