Vascular endothelial growth factor receptor 2–mediated angiogenesis is essential for gonadotropin-dependent follicle development
J. Clin. Invest. Ralf C. Zimmermann, et al. 112:659 doi:10.1172/JCI18740 [Go to this article.]

Figure 1
(a) H&E staining of mouse ovaries on experimental day 3. Top panel, low-power photomicrographs of three representative whole ovaries from HX animals not treated with hormone (C, control); no advanced antral stage follicles present. Middle panel, low-power photomicrographs of three representative whole ovaries from HX animals stimulated with PMSG (S, stimulation); at least three advanced antral stage follicles present in each section. Lower panel, low-power photomicrographs of three representative whole ovaries from HX animals treated with PMSG plus anti–VEGFR-2 Ab (T, treatment); early antral stage follicles present in each section. (b) Intermediate-power photomicrographs of a control, stimulation, and treatment ovary (boxed area in a). Numbers indicate classes of follicular development. (c) Follicle classification.