Critical role of IL-10 in the induction of low zone tolerance to contact allergens
J. Clin. Invest. Marcus Maurer, et al. 112:432 doi:10.1172/JCI18106 [
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Figure 1IL-10 is required for the induction of LZT, whereas CHS prevention in tolerized mice is IL-10 independent. Expression of LZT quantified by assessing allergic inflammatory responses (ear swelling) after TNCB challenge in
IL-10+/+ mice and
IL-10–/– mice that were treated repeatedly with low doses of contact allergen (TNCB) to induce LZT and then sensitized to TNCB. Some
IL-10–/– mice were reconstituted with IL-10 during tolerization (the induction phase of LZT) or during sensitization (the effector phase of LZT). Data represent relative (
a) and absolute (
b) changes in ear thickness (means ± SEM) pooled from six or more mice per treatment group from one of three independent experiments with similar results.
#P < 0.001.
