Luminal NaCl delivery regulates basolateral PGE₂ release from macula densa cells
J. Clin. Invest. János Peti-Peterdi, et al. 112:76 doi:10.1172/JCI18018 [Go to this article.]

Figure 4
Biosensor HEK/EP1 cell baseline [Ca²⁺]i (a) and tubular NaCl removal–induced increases in [Ca²⁺]i (Δ[Ca²⁺]i) (b). A low-salt diet significantly elevated biosensor cell baseline [Ca²⁺]i and Δ[Ca²⁺]i upon luminal NaCl removal, compared with a normal diet. Biosensor cell calcium responses were inhibited by luminal addition of a selective COX-2 inhibitor (SC58236, 100 nM) or bath SC51322 (10 μM), an EP1 blocker. (n = 6 in each group, *P < 0.01 compared with normal diet).