Luminal NaCl delivery regulates basolateral PGE₂ release from macula densa cells
J. Clin. Invest. János Peti-Peterdi, et al. 112:76 doi:10.1172/JCI18018 [Go to this article.]

Figure 3
Representative recordings of changes in HEK/EP1 [Ca²⁺]i/MD PGE2 release. (a) Luminal NaCl removal in the low-salt group (in contrast to normal diet) induced significant PGE2 release from MD, but not from distant cTAL cells, as evidenced by increases in HEK/EP1 [Ca²⁺]i. (b) HEK/EP1 calcium responses (low-salt group) were inhibited by either luminal addition of furosemide, an Na:2Cl:K cotransport blocker, or by a selective COX-2 inhibitor (SC58236, 100 nM) or bath SC51322 (10 μM), an EP1 blocker.