P2Y₁₂ regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
J. Clin. Invest. Patrick André, et al. 112:398 doi:10.1172/JCI17864 [Go to this article.]

Figure 6
Perfusion chamber experiments. (a) Washed platelets resuspended in presence of botrocetin were perfused through a human vWF-coated capillary at 871/s for 4 minutes. (b) Non-anticoagulated whole blood was perfused over fibrinogen at 871/s for 2.5 minutes. No differences were observed between WT and P2Y₁₂^–/– blood. (c) Twenty-five perfusion chambers were used to establish the mean gray level thrombotic profile in the 345-μm diameter capillary, including WT, P2Y₁₂^–/–, and P2Y₁₂^–/– mice treated with ASA. (d) ASA-treated or untreated non-anticoagulated blood of WT or P2Y₁₂^–/– mice was perfused over collagen at 871/s. Epinephrine infusion (50 μM) corrects the inhibition observed with the combination P2Y₁₂ deficiency/ASA uptake (10 mg/kg). Values were expressed as the mean ± SEM of at least six animals per group.*P < 0.001.