P2Y₁₂ regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
J. Clin. Invest. Patrick André, et al. 112:398 doi:10.1172/JCI17864 [Go to this article.]

Figure 2
Aggregation measurements in PRP obtained from WT (+/+), P2Y₁₂^–/– (–/–), or P2Y₁₂^+/– (+/–) mice in response to (a) 0.5 μM ADP, (b) 10 μM ADP, (c) 1 μg/ml collagen, (d) 20 μg/ml collagen, (e) 1 mM mTRAP, and (f) 2.5 mM mTRAP. Traces are representative of data obtained from two independent experiments (blood from four mice pooled for each experiment). (g) Tail bleeding times for WT (n = 14), P2Y₁₂^+/– (n = 18), and P2Y₁₂^–/– mice (n = 15) littermates. Values are expressed as mean ± SEM. *P < 0.01 versus WT and P2Y₁₂^+/– mice (using Dunnett test).