DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response
J. Clin. Invest. Avishai Mimran, et al. 113:924 doi:10.1172/JCI17772 [
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Figure 7DNA vaccination with CD25 induces T cell responses to CD25 peptides in protected rats. DLN cells from each of the four groups, nontreated (MSP = 159 cpm), pcDNA3-vaccinated (MSP = 198 cpm), CD25-vaccinated (MSP = 223 cpm), and CD132-vaccinated (MSP = 305 cpm), were pooled from three rats, and their antiergotypic responses were measured on day 22 after AA induction. Two α-chain (a1, a2) peptides were used as ergotopes. A control peptide from the p53 protein (p53-1) was included. Proliferative responses are presented as the SI ± SEM of quadruplicate cultures. *
P < 0.02 compared with the nonprotected CD132-vaccinated group for the two peptides.
