DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response
J. Clin. Invest. Avishai Mimran, et al. 113:924 doi:10.1172/JCI17772 [
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Figure 5The antiergotypic T cell response in naive rats is downregulated by AA induction. LN cells from (A) naive rats (MSP = 153 cpm) or (B) DLN cells from rats at day 22 of AA induction (MSP = 159 cpm) were pooled from three rats and were measured for the T cell response to A6-S or A6-R at different stimulator cell concentrations. The decrease in the response to activated T cells is significant:
P < 0.02 for all stimulator cell concentrations, compared with the naive rats (A). Proliferative responses are presented as the SI ± SEM of quadruplicate cultures. This is a representative experiment of three repetitions.
