In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
J. Clin. Invest. Bruno B. Bordier, et al. 112:407 doi:10.1172/JCI17704 [Go to this article.]

Figure 3
Design and structures of prenylation inhibitors used to treat HDV viremia. (a) Cys-Val-Ile-Met CXXX box tetrapeptide as found in K-Ras4B, a substrate of farnesyltransferase. Two peptidomimetics of this CXXX box were designed as, and shown to be, competitive inhibitors of farnesyltransferase, (b) FTI-277, wherein the dipeptide Val-Ile is replaced by 2-phenyl-4-aminobenzoic acid, and (c) FTI-2153, wherein the tripeptide Cys-Val-Ile is replaced by an imidazole derivative of 2-(2-methylphenyl)-4-aminomethylbenzoic acid.