A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor–deficient mice
J. Clin. Invest. Natalie A. Sims, et al. 111:1319 doi:10.1172/JCI17246 [
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Figure 1Response of WT and ER knockout mice to gonadectomy. Mice were sham-operated (black bars) or gonadectomized (white bars) at 12 weeks of age, and bones were collected after 8 weeks. (
a) Tb.BMD and BV/TV were significantly reduced in male mice of all genotypes after orchidectomy. (
b) Tb.BMD and BV/TV were significantly reduced after ovariectomy in female mice of all genotypes except ERαβ
–/–. Values are mean ± SEM. *
P < 0.05, **
P < 0.01, ***
P < 0.001 vs. sham-operated of the same genotype.
