A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia
J. Clin. Invest. Shigeki Katoh, et al. 111:1563 doi:10.1172/JCI16583 [Go to this article.]

Figure 5
Effect of anti-CD44 mAb on allergen-induced airway hyperresponsiveness to methacholine. Airway responsiveness to aerosolized methacholine was measured in conscious mice as described in Methods, and sRaw values were determined. Expressed are the means ± SEM of the increase in sRaw values compared with sRaw values after PBS nebulization from five independent experiments. ^#Significant differences (P < 0.05) between Asc-challenged RIgG-treatment mice (Asc/RIgG) and PBS-challenged mice (PBS). *Significant differences (P < 0.05) between Asc-challenged anti-CD44 mAb-treatment mice (Asc/IM7 or Asc/KM201) and Asc-challenged RIgG-treatment mice (Asc/RIgG).