Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
J. Clin. Invest. Raymond J. Steptoe, et al. 111:1357 doi:10.1172/JCI15995 [Go to this article.]

Figure 1
Transplantation of NOD-PI BM inhibits development of diabetes. (a) The incidence of diabetes was significantly reduced in recipients of NOD-PI BM (inverted triangles) as compared with NOD BM (triangles) (P = 0.003) or untreated NOD mice (squares) (P = 0.001). NOD BM recipients did not differ from the untreated controls. Data are pooled from two experiments in which BMT from NOD-PI mice or NOD mice was performed in parallel. (b) The incidence of diabetes was significantly reduced in recipients of T cell–depleted NOD-PI BM (inverted triangles) as compared with T cell–depleted NOD BM (triangles) (P = 0.003) or untreated NOD mice (squares) (P = 0.036). NOD BM recipients did not differ from untreated controls. Data are pooled from three experiments in which BMT from NOD-PI or NOD mice was performed in parallel. Cumulative incidence of diabetes is shown on the y-axis and the age of mice in days on the x-axis.