Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
J. Clin. Invest. Andrew C. Li, et al. 106:523 doi:10.1172/JCI10370 [Go to this article.]

Figure 1
Atherosclerosis in LDLR^–/– mice fed a high-fat, cholesterol-enriched Western diet for 10 weeks. (a) Sections through the aortic root at the levels of the aortic valves were stained for elastin to highlight the medial boundaries of atherosclerotic lesions. (b) Quantitative analysis of lesion areas in control mice (C), mice treated with rosiglitazone (Ro), and mice treated with GW7845 (GW). For male mice, means ± SEM were: C, 0.161 ± 0.067 mm²/section (n = 10); Ro, 0.037 ± 0.014 mm²/section (n = 12); GW, 0.063 ± 0.027 mm²/section (n = 10). For female mice, means ± SEM were: C, 0.131 ± 0.035 mm²/section (n = 10); Ro, 0.183 ± 0.0.088 mm²/section (n = 10); GW, 0.181±0.0091 mm²/section (n = 10). NS, not statistically significant.