Regulation of radiation-induced protein kinase Cδ activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma …
T Nakajima, O Yukawa, H Tsuji, H Ohyama… - Mutation Research …, 2006 - Elsevier
Protein kinase Cδ (PKCδ) has an important role in radiation-induced apoptosis. The
expression and function of PKCδ in radiation-induced apoptosis were assessed in a
radiation-sensitive mouse thymic lymphoma cell line, 3SBH5, and its radioresistant variant,
XR223. Rottlerin, a PKCδ-specific inhibitor, completely abolished radiation-induced
apoptosis in 3SBH5. Radiation-induced PKCδ activation correlated with the degradation of
PKCδ, indicating that PKCδ activation through degradation is involved in radiation-induced …
expression and function of PKCδ in radiation-induced apoptosis were assessed in a
radiation-sensitive mouse thymic lymphoma cell line, 3SBH5, and its radioresistant variant,
XR223. Rottlerin, a PKCδ-specific inhibitor, completely abolished radiation-induced
apoptosis in 3SBH5. Radiation-induced PKCδ activation correlated with the degradation of
PKCδ, indicating that PKCδ activation through degradation is involved in radiation-induced …