Abstract:  The cutaneous environment hosts a number of hematopoietic neoplasms that are dominated by primary cutaneous (PC) T‐cell lymphomas. Recent progress in molecular biology and immunology has provided tools to investigate the pathogenesis and the biology of these neoplasms. This review highlights newest findings concerning the immune biology of CD4⁺CD56⁺ hematodermic neoplasms, and PC T‐cell and B‐cell lymphomas, speculating how these can be translated into more sophisticated, biology‐based treatment approaches in the near future.