The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial
cells contribute to vascular tone, regulation of blood flow to local tissue beds, modulation of
coagulation and inflammation, and vascular permeability. Both ischemia and sepsis have
profound effects on the renal endothelium, resulting in microvascular dysregulation resulting
in continued ischemia and further injury. In recent years, the concept of the vascular …