Role of Ras signaling in the induction of snail by transforming growth factor-β
K Horiguchi, T Shirakihara, A Nakano, T Imamura… - Journal of Biological …, 2009 - jbc.org
The epithelial-mesenchymal transition (EMT) is a crucial morphological event that occurs
during the progression of epithelial tumors. EMT can be induced by transforming growth
factor (TGF)-β in some tumor cells. Here, we demonstrate the molecular mechanism
whereby Snail, a key regulator of EMT, is induced by TGF-β in tumor cells. Snail induction by
TGF-β was highly dependent on cooperation with active Ras signals, and silencing of Ras
abolished Snail induction by TGF-β in pancreatic cancer Panc-1 cells. Transfection of …
during the progression of epithelial tumors. EMT can be induced by transforming growth
factor (TGF)-β in some tumor cells. Here, we demonstrate the molecular mechanism
whereby Snail, a key regulator of EMT, is induced by TGF-β in tumor cells. Snail induction by
TGF-β was highly dependent on cooperation with active Ras signals, and silencing of Ras
abolished Snail induction by TGF-β in pancreatic cancer Panc-1 cells. Transfection of …
