Importance The association between the use of antidepressants during gestation and the
risk of autism spectrum disorder (ASD) in children is still controversial. The etiology of ASD
remains unclear, although studies have implicated genetic predispositions, environmental
risk factors, and maternal depression. Objective To examine the risk of ASD in children
associated with antidepressant use during pregnancy according to trimester of exposure
and taking into account maternal depression. Design, Setting, and Participants We …