AXL+ SIGLEC6+ dendritic cells in cerebrospinal fluid and brain tissues of patients with autoimmune inflammatory demyelinating disease of CNS
J Kang, M Kim, DY Yoon, WS Kim, SJ Choi, YN Kwon… - Clinical …, 2023 - Elsevier
Inflammatory demyelinating disease of the CNS (IDD) is a heterogeneous group of
autoimmune diseases, and multiple sclerosis is the most common type. Dendritic cells
(DCs), major antigen-presenting cells, have been proposed to play a central role in the
pathogenesis of IDD. The AXL+ SIGLEC6+ DC (ASDC) has been only recently identified in
humans and has a high capability of T cell activation. Nevertheless, its contribution to CNS
autoimmunity remains still obscure. Here, we aimed to identify the ASDC in diverse sample …
autoimmune diseases, and multiple sclerosis is the most common type. Dendritic cells
(DCs), major antigen-presenting cells, have been proposed to play a central role in the
pathogenesis of IDD. The AXL+ SIGLEC6+ DC (ASDC) has been only recently identified in
humans and has a high capability of T cell activation. Nevertheless, its contribution to CNS
autoimmunity remains still obscure. Here, we aimed to identify the ASDC in diverse sample …