Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets

M Grima-Terrén, S Campanario… - Molecular Aspects of …, 2024 - Elsevier
Sarcopenia is a progressive muscle wasting disorder that severely impacts the quality of life
of elderly individuals. Although the natural aging process primarily causes sarcopenia, it can
develop in response to other conditions. Because muscle function is influenced by
numerous changes that occur with age, the etiology of sarcopenia remains unclear.
However, recent characterizations of the aging muscle transcriptional landscape, signaling
pathway disruptions, fiber and extracellular matrix compositions, systemic metabolomic and …