[HTML][HTML] Gushukang inhibits osteocyte apoptosis and enhances BMP-2/Smads signaling pathway in ovariectomized rats
S Chai, L Wan, JL Wang, JC Huang, HX Huang - Phytomedicine, 2019 - Elsevier
Abstract Background Traditional herbal formula Gushukang (GSK) has been clinically
applied to treat primary osteoporosis, which can stimulate osteoblastogenesis and improve
calcium homeostasis. However, it remains unknown the mechanism that GSK against
ovariectomized (OVX) induced damage. Purpose The aim of this study was to investigate the
effect of GSK on BMP-2/Smsds signaling pathway and osteocyte apoptosis which has been
reported to play a central role in bone remodeling. Study design OVX in rat was established …
applied to treat primary osteoporosis, which can stimulate osteoblastogenesis and improve
calcium homeostasis. However, it remains unknown the mechanism that GSK against
ovariectomized (OVX) induced damage. Purpose The aim of this study was to investigate the
effect of GSK on BMP-2/Smsds signaling pathway and osteocyte apoptosis which has been
reported to play a central role in bone remodeling. Study design OVX in rat was established …