Importance Cannabis dependence (CAD) is a serious problem worldwide and is of growing
importance in the United States because cannabis is increasingly available legally.
Although genetic factors contribute substantially to CAD risk, at present no well-established
specific genetic risk factors for CAD have been elucidated. Objective To report findings
forDSM-IVCAD criteria from association analyses performed in large cohorts of African
American and European American participants from 3 studies of substance use disorder …