Two are the issues on cannabis addiction that provoke more controversy from a research
perspective. The first one is related to the development of tolerance phenomena and, in
particular, of a dependence state after chronic cannabinoid consumption, with appearance
of withdrawal signs when this is interrupted, that would be (or not) comparable to those
observed for other drugs. A second controversial issue is related to the possibility that
chronic cannabinoid consumption may increase the risk to consume other drugs of greater …