Cutaneous T-cell recruitment in toxic epidermal necrolysis: further evidence of CD8+ lymphocyte involvement
O Correia, L Delgado, JP Ramos… - Archives of …, 1993 - jamanetwork.com
• Background.—Toxic epidermal necrolysis (TEN) is a life-threatening disease with severe
mucocutaneous shedding. Although it is widely accepted that immune mechanisms are at
play, the pathophysiology of TEN is still unknown. We studied the blister fluid inflammatory
cells in three drugrelated cases to further define the suspected T-cell involvement in TEN.
Observations.—A peripheral blood lymphopenia, especially of CD4+ T lymphocytes, was
associated with a high lymphocytic cellularity of the blister fluid. In two cases …
mucocutaneous shedding. Although it is widely accepted that immune mechanisms are at
play, the pathophysiology of TEN is still unknown. We studied the blister fluid inflammatory
cells in three drugrelated cases to further define the suspected T-cell involvement in TEN.
Observations.—A peripheral blood lymphopenia, especially of CD4+ T lymphocytes, was
associated with a high lymphocytic cellularity of the blister fluid. In two cases …
