A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
FK Wiseman, T Al-Janabi, J Hardy… - Nature reviews …, 2015 - nature.com
Nature reviews neuroscience, 2015•nature.com
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that
this risk is conferred by the presence of three copies of the gene encoding amyloid precursor
protein (APP)—an Alzheimer disease risk factor—although the possession of extra copies of
other chromosome 21 genes may also play a part. Further study of the mechanisms
underlying the development of Alzheimer disease in people with Down syndrome could …
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that
this risk is conferred by the presence of three copies of the gene encoding amyloid precursor
protein (APP)—an Alzheimer disease risk factor—although the possession of extra copies of
other chromosome 21 genes may also play a part. Further study of the mechanisms
underlying the development of Alzheimer disease in people with Down syndrome could …
Abstract
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP) — an Alzheimer disease risk factor — although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in people with Down syndrome could provide insights into the mechanisms that cause dementia in the general population.
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