4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
F Poulin, AC Gingras, H Olsen, S Chevalier… - Journal of Biological …, 1998 - jbc.org
Translation initiation in eukaryotes is mediated by the cap structure (m 7 GpppN, where N is
any nucleotide) present at the 5′ end of all cellular mRNAs, except organellar. The cap is
recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides,
including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E
facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by two
translational repressors, 4E-BP1 and 4E-BP2, which bind to it and prevent its assembly into …
any nucleotide) present at the 5′ end of all cellular mRNAs, except organellar. The cap is
recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides,
including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E
facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by two
translational repressors, 4E-BP1 and 4E-BP2, which bind to it and prevent its assembly into …
