Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor β
P Guo, XY Dong, K Zhao, X Sun, Q Li… - Journal of Biological …, 2009 - jbc.org
The proto-oncogene MYC plays a critical role in cell proliferation and tumorigenesis, and its
down-regulation by transforming growth factor β (TGFβ) signaling is necessary for TGFβ to
inhibit cell proliferation. KLF5, on the other hand, is a pro-proliferative basic transcription
factor that reverses function to become an anti-proliferative TGFβ cofactor upon TGFβ
stimulation in epithelial homeostasis. In this study we investigated whether KLF5 directly
regulates MYC transcription in epithelial cells in the context of TGFβ. Knockdown of KLF5 …
down-regulation by transforming growth factor β (TGFβ) signaling is necessary for TGFβ to
inhibit cell proliferation. KLF5, on the other hand, is a pro-proliferative basic transcription
factor that reverses function to become an anti-proliferative TGFβ cofactor upon TGFβ
stimulation in epithelial homeostasis. In this study we investigated whether KLF5 directly
regulates MYC transcription in epithelial cells in the context of TGFβ. Knockdown of KLF5 …
