A region in the C-terminal domain of ribosomal protein SA required for binding of SA to the human 40S ribosomal subunit
AA Malygin, ES Babaylova, VB Loktev, GG Karpova - Biochimie, 2011 - Elsevier
The human ribosomal protein SA, known also as a precursor of the cell-surface laminin
receptor, LAMR, is a protein of the 40S ribosomal subunit. It is homologous to eubacterial
ribosomal protein S2p, but has a eukaryote-specific C-terminal domain (CTD) that is
responsible in LAMR for the binding of laminin as well as prions and several viruses. Using
serial deletions in the SA CTD, we showed that region between amino acids 236–262 is
required for binding of the protein to 40S ribosomal subunits. All SA mutants containing this …
receptor, LAMR, is a protein of the 40S ribosomal subunit. It is homologous to eubacterial
ribosomal protein S2p, but has a eukaryote-specific C-terminal domain (CTD) that is
responsible in LAMR for the binding of laminin as well as prions and several viruses. Using
serial deletions in the SA CTD, we showed that region between amino acids 236–262 is
required for binding of the protein to 40S ribosomal subunits. All SA mutants containing this …