Tuning macrocycles to design 'turn-on'fluorescence probes for manganese (II) sensing in live cells
Chemical Communications, 2015•pubs.rsc.org
We tune the coordination environment of macrocyclic ligands to design two novel
fluorescence sensors for Mn2+. The BODIPY-based Mn2+ sensor M1 affords an excellent,
52 fold, fluorescence 'turn-on'response despite the paramagnetic nature of Mn2+. The
lipophilic probe is cell-permeable and confocal imaging demonstrates that the sensor
distinctly detects Mn2+ within live cells.
fluorescence sensors for Mn2+. The BODIPY-based Mn2+ sensor M1 affords an excellent,
52 fold, fluorescence 'turn-on'response despite the paramagnetic nature of Mn2+. The
lipophilic probe is cell-permeable and confocal imaging demonstrates that the sensor
distinctly detects Mn2+ within live cells.
We tune the coordination environment of macrocyclic ligands to design two novel fluorescence sensors for Mn2+. The BODIPY-based Mn2+ sensor M1 affords an excellent, 52 fold, fluorescence ‘turn-on’ response despite the paramagnetic nature of Mn2+. The lipophilic probe is cell-permeable and confocal imaging demonstrates that the sensor distinctly detects Mn2+ within live cells.
The Royal Society of Chemistry