RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency
OK Alkhairy, N Rezaei, RR Graham… - Journal of Allergy and …, 2015 - jacionline.org
RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable
immunodeficiency in IL-10 and IL-13 regulation in monocytes. Therefore we treated PBMCs
from patients with AD who were sensitized to Mala s 13 with lactic acid to remove surface-
bound IgE. E3, E4 By using this treatment, surface levels of IgE on monocytes were reduced
(Fig 1, D), and IL-10 secretion was significantly increased after Mala s 13 stimulation but not
after hTrx stimulation (Fig 1, E). In contrast, IL-13 secretion could be reduced after lactic acid …
immunodeficiency in IL-10 and IL-13 regulation in monocytes. Therefore we treated PBMCs
from patients with AD who were sensitized to Mala s 13 with lactic acid to remove surface-
bound IgE. E3, E4 By using this treatment, surface levels of IgE on monocytes were reduced
(Fig 1, D), and IL-10 secretion was significantly increased after Mala s 13 stimulation but not
after hTrx stimulation (Fig 1, E). In contrast, IL-13 secretion could be reduced after lactic acid …
