Blocking Bcl-2 resolves IL-13–mediated mucous cell hyperplasia in a Bik-dependent manner
HS Chand, YA Mebratu, PJ Kuehl… - Journal of Allergy and …, 2017 - jacionline.org
To the Editor: Bcl-2 protects cells against a wide range of apoptotic stimuli by preventing
mitochondrial permeabilization caused by proapoptotic Bcl-2 family members. 1 Although
Bcl-2 levels are regulated by various cytokines, 2 inflammatory mediators that affect Bcl-2
expression in nonhematopoietic primary cells have been studied poorly. Bcl-2 expression is
upregulated in airway mucous cells of patients with chronic bronchitis, asthmatic bronchitis,
and cystic fibrosis and in respective animal models to sustain hyperplastic mucous cells. 3, 4 …
mitochondrial permeabilization caused by proapoptotic Bcl-2 family members. 1 Although
Bcl-2 levels are regulated by various cytokines, 2 inflammatory mediators that affect Bcl-2
expression in nonhematopoietic primary cells have been studied poorly. Bcl-2 expression is
upregulated in airway mucous cells of patients with chronic bronchitis, asthmatic bronchitis,
and cystic fibrosis and in respective animal models to sustain hyperplastic mucous cells. 3, 4 …
