ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter
BN Atkinson, SC Bell, M De Vivo, LR Kowalski… - Molecular …, 2001 - Elsevier
High-affinity glycine transport in neurons and glial cells is a primary means of inactivating
synaptic glycine. We have synthesized a potent selective inhibitor of glycine transporter 1
(GlyT1), and characterized its activity using a quail fibroblast cell line (QT6). The glycine
transporters GlyT1A, GlyT1B, GlyT1C, and GlyT2 were stably expressed in QT6 cells. The
transporters expressed in these cells exhibited appropriate characteristics as described
previously for these genes: Na+/Cl− dependence, appropriate K m values for glycine uptake …
synaptic glycine. We have synthesized a potent selective inhibitor of glycine transporter 1
(GlyT1), and characterized its activity using a quail fibroblast cell line (QT6). The glycine
transporters GlyT1A, GlyT1B, GlyT1C, and GlyT2 were stably expressed in QT6 cells. The
transporters expressed in these cells exhibited appropriate characteristics as described
previously for these genes: Na+/Cl− dependence, appropriate K m values for glycine uptake …