Foetal growth restriction (FGR) and associated placental pathologies such as pre-eclampsia
and stillbirth arise in early pregnancy when inadequate remodelling of maternal spiral
arteries leads to persistent high-resistance low-flow uteroplacental circulation. Current
interventions concentrate on targeting the placental ischaemia-reperfusion injury and
oxidative stress associated with an imbalance in angiogenic/anti-angiogenic factors. Recent
meta-analyses confirm that aspirin modestly reduces the risk for small-for-gestational-age …