KATP channels in lymphatic function
MJ Davis, HJ Kim, CG Nichols - American Journal of …, 2022 - journals.physiology.org
MJ Davis, HJ Kim, CG Nichols
American Journal of Physiology-Cell Physiology, 2022•journals.physiology.orgKATP channels function as negative regulators of active lymphatic pumping and lymph
transport. This review summarizes and critiques the evidence for the expression of specific
KATP channel subunits in lymphatic smooth muscle and endothelium, the roles that they
play in normal lymphatic function, and their possible involvement in multiple diseases,
including metabolic syndrome, lymphedema, and Cantú syndrome. For each of these topics,
suggestions are made for directions for future research.
transport. This review summarizes and critiques the evidence for the expression of specific
KATP channel subunits in lymphatic smooth muscle and endothelium, the roles that they
play in normal lymphatic function, and their possible involvement in multiple diseases,
including metabolic syndrome, lymphedema, and Cantú syndrome. For each of these topics,
suggestions are made for directions for future research.
KATP channels function as negative regulators of active lymphatic pumping and lymph transport. This review summarizes and critiques the evidence for the expression of specific KATP channel subunits in lymphatic smooth muscle and endothelium, the roles that they play in normal lymphatic function, and their possible involvement in multiple diseases, including metabolic syndrome, lymphedema, and Cantú syndrome. For each of these topics, suggestions are made for directions for future research.
American Physiological Society