Human cytomegalovirus: coordinating cellular stress, signaling, and metabolic pathways

T Shenk, JC Alwine - Annual review of virology, 2014 - annualreviews.org
Viruses face a multitude of challenges when they infect a host cell. Cells have evolved
innate defenses to protect against pathogens, and an infecting virus may induce a stress
response that antagonizes viral replication. Further, the metabolic, oxidative, and cell cycle
state may not be conducive to the viral infection. But viruses are fabulous manipulators,
inducing host cells to use their own characteristic mechanisms and pathways to provide
what the virus needs. This article centers on the manipulation of host cell metabolism by …