Tissue macrophages: heterogeneity and functions
S Gordon, A Plüddemann - BMC biology, 2017 - Springer
S Gordon, A Plüddemann
BMC biology, 2017•SpringerMacrophages are present in all vertebrate tissues, from mid-gestation throughout life,
constituting a widely dispersed organ system. They promote homeostasis by responding to
internal and external changes within the body, not only as phagocytes in defence against
microbes and in clearance of dead and senescent cells, but also through trophic, regulatory
and repair functions. In this review, we describe macrophage phenotypic heterogeneity in
different tissue environments, drawing particular attention to organ-specific functions.
constituting a widely dispersed organ system. They promote homeostasis by responding to
internal and external changes within the body, not only as phagocytes in defence against
microbes and in clearance of dead and senescent cells, but also through trophic, regulatory
and repair functions. In this review, we describe macrophage phenotypic heterogeneity in
different tissue environments, drawing particular attention to organ-specific functions.
Abstract
Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions.
Springer
