[HTML][HTML] Intranasal insulin reduces white matter hyperintensity progression in association with improvements in cognition and CSF biomarker profiles in mild cognitive …
Background Intranasally administered insulin has shown promise in both rodent and human
studies in Alzheimer's disease; however, both effects and mechanisms require elucidation.
Objective We assessed the effects of intranasally administered insulin on white matter health
and its association with cognition and cerebral spinal fluid biomarker profiles in adults with
mild cognitive impairment or Alzheimer's disease in secondary analyses from a prior phase
2 clinical trial (NCT01767909). Design A randomized (1: 1) double-blind clinical trial. Setting …
studies in Alzheimer's disease; however, both effects and mechanisms require elucidation.
Objective We assessed the effects of intranasally administered insulin on white matter health
and its association with cognition and cerebral spinal fluid biomarker profiles in adults with
mild cognitive impairment or Alzheimer's disease in secondary analyses from a prior phase
2 clinical trial (NCT01767909). Design A randomized (1: 1) double-blind clinical trial. Setting …