Epigenetics in β-cell adaptation and type 2 diabetes
H Kim, RN Kulkarni - Current opinion in pharmacology, 2020 - Elsevier
Healthy pancreatic β-cells adapt to systemic insulin resistance to maintain normal blood
glucose levels, and a failure of this adaptation leads to type 2 diabetes in humans. While
genome-wide association studies have uncovered genetic variants that are associated with
type 2 diabetes, it is still insufficient to explain the high prevalence of this disease.
Epigenetics is the study of gene expression changes that do not involve DNA sequence
alterations such as DNA methylation, histone modification, and non-coding RNAs. Over the …
glucose levels, and a failure of this adaptation leads to type 2 diabetes in humans. While
genome-wide association studies have uncovered genetic variants that are associated with
type 2 diabetes, it is still insufficient to explain the high prevalence of this disease.
Epigenetics is the study of gene expression changes that do not involve DNA sequence
alterations such as DNA methylation, histone modification, and non-coding RNAs. Over the …